The U.S. Preventive Services Task Force now recommends that all adults in this age range be screened for hepatitis C virus (HCV) at least once, regardless of risk factors. Universal HCV screening was previously recommended only for those born between 1945 and 1965. People outside this age range should also be screened if they are at risk. Early detection and prompt treatment of hepatitis C can prevent liver cancer and the need for a liver transplant.