Generic Name: brentuximab vedotin
Drug Class: Targeted Therapy Medications
Company: Seattle Genetics
Approval Status: Approved
Generic Version Available: No
Adcetris is a CD30-directed antibody-drug conjugate approved for anaplastic large cell lymphoma, classical Hodgkin lymphoma and peripheral T-cell lymphoma.
Adcetris consists of an antibody that binds to the CD30 receptor on cancerous B cells plus the strong chemotherapy drug monomethyl auristatin E. This drug is too toxic to use as a systemic medication by itself, but the antibody carries it directly to cancer cells.
Clinical trials showed that Adcetris slows disease progression in people with anaplastic large cell lymphoma and classical Hodgkin lymphoma.
Adcetris is an intravenous infusion administered every two or three weeks.
Common side effects include fatigue, nausea, constipation, diarrhea, fever and peripheral neuropathy. Adcetris can cause depletion of white blood cells (neutropenia), which can lead to infections, including fatal opportunistic infections. Other potentially serious side effects include liver toxicity, lung toxicity, severe skin reactions and tumor lysis syndrome, or metabolic abnormalities that can occur when many cancer cells are killed at once.
For More Info: https://www.adcetris.com
Patient Assistance Program Info: https://www.pparx.org/prescription_assistance_programs/seagen_secure_patient_assistance_program
Last Reviewed: November 16, 2018