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In tumors with missing or mutated BRCA genes, PARP inhibitors plus other drugs have worked well—but the cancer often becomes drug-resistant.
Dietary or drug interventions could counteract resistance to PI3K inhibitors in many tumors.
This finding could lead to clinical trials specifically for men with treatment-emergent small-cell neuroendocrine prostate cancer.
Treatment-resistant cancers self-destruct when exposed to experimental drug.
The cells’ immediate response was to change the mechanisms they use to evade treatment and start dividing again—in just a few days.
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