#drug resistance

Acquired resistance has sent many researchers back to the lab in an effort to uncover its cause, and new tools that may help to overcome it.

Several studies focused on this topic were recently reported on at the AACR-Melanoma Conference.

HIV, anti-vaxxers, dengue fever and weak primary health care make the World Health Organization’s list of priorities.

The discovery points the way toward a new strategy for precision cancer therapy.

In tumors with missing or mutated BRCA genes, PARP inhibitors plus other drugs have worked well—but the cancer often becomes drug-resistant.

Dietary or drug interventions could counteract resistance to PI3K inhibitors in many tumors.

This finding could lead to clinical trials specifically for men with treatment-emergent small-cell neuroendocrine prostate cancer.

Treatment-resistant cancers self-destruct when exposed to experimental drug.

The cells’ immediate response was to change the mechanisms they use to evade treatment and start dividing again—in just a few days.