Generic Name: apalutamide
Drug Class: Hormone Therapy Medications
Approval Status: Approved
Generic Version Available: No
Erleada is an androgen receptor inhibitor approved for nonmetastatic prostate cancer that progresses despite low testosterone levels (known as castration resistant).
Testosterone and other male hormones (androgens) stimulate prostate cancer growth. To do so, they must to bind to androgen receptors on prostate cells. Erleada blocks signals from androgen receptors, preventing them from triggering hormone production. It should be combined with drugs such as GnRH agonists that reduce testosterone production, known as androgen deprivation therapy (ADT).
In the SPARTAN trial, Erleada plus androgen deprivation therapy delayed prostate cancer metastasis and improved progression-free survival compared to ADT alone.
Erleada is taken as pill. The usual dose is four tablets taken together once daily with or without food.
Common side effects include fatigue, skin rash, hot flashes, diarrhea, nausea, decreased appetite, weight loss, joint pain, high blood pressure and swelling. Seizures are a less common but potentially serious side effect. Erleada has been associated with an increased risk of falling and bone fractures.
For More Info: https://www.erleada.com/
Co-Pay Program Info: http://www.janssenprescriptionassistance.com/
Patient Assistance Program Info: http://www.janssenprescriptionassistance.com/
Last Reviewed: September 19, 2018