Generic Name: lorlatinib
Drug Class: Targeted Therapy Medications
Approval Status: Approved
Generic Version Available: No
Lorbrena is an anaplastic lymphoma kinase inhibitor approved for people with previously treated ALK-positive non-small-cell lung cancer.
Lorbrena interferes with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase, a protein that plays a role in cell growth.
In a Phase I/II study, Lorbrena led to tumor shrinkage in 48 percent of people with ALK-positive metastatic non-small-cell lung cancer who were previously treated with older ALK inhibitors.
Dosing Info: Talzenna is taken as a once-daily tablet.
Common side effects include swelling, peripheral neuropathy, cognitive and mood effects, shortness of breath, fatigue, weight gain, joint pain and diarrhea. Lorbrena can cause serious liver toxicity when used with other medications that are strong CYP3A inducers. The Lorbrena label includes a warning about central nervous system side effects including seizures, hallucinations, and changes in cognitive function, mood, mental status and sleep. It may also cause elevated blood lipids, heart problems or lung inflammation (pneumonitis).
For More Info: https://www.lorbrena.com/
Patient Assistance Program Info: https://www.lorbrena.com/personalized-support
Last Reviewed: November 2, 2018