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In tumors with missing or mutated BRCA genes, PARP inhibitors plus other drugs have worked well—but the cancer often becomes drug-resistant.
The approach, called an implantable cancer treatment vaccine, is being tested in a small phase 1 clinical trial.
“With all the challenges Kevin faced, he was reminded by our mother what a gift life is.”
Physicians recognize that ovarian cancer isn’t a single disease but a group of related disorders with distinct genetic and cellular features
As mutations occur, a cell may gain the ability to grow without restraint and invade nearby tissue— to become, in effect, a cancer cell.
Turns out mutations in the TP53 gene are focused on so-called “hot spots” because specific carcinogens target those spots.
The results led to a new initiative launched with the support of actress Mira Sorvino.
Fast facts, common myths and misconceptions
A new area of research is examining the use of checkpoint inhibitors before surgery, a practice known as neoadjuvant therapy.
NK cells are “first responders” that rapidly detect and attack virus-infected cells and tumor cells, and can also help prevent metastasis.
“To make a significant impact in treating this kind of cancer, we need to find it earlier,” says medical oncologist Brian Wolphin, MD, MPH...
The findings lay the groundwork for tests that can identify whether the disease is likely to progress rapidly.
Tara Shuman says she feels lucky “to be able to reach out and connect with so many people going through cancer.”
Researchers say it would be ideal to have future clinical trials in which tissue-based biomarker studies dictate treatment options.
There is no concrete evidence that a ketogenic diet will benefit cancer patients and results from clinical trials have yet to be revealed.
The researchers say their discovery suggests potential new targeted therapeutic strategies for the disease.
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