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Imfinzi plus chemotherapy led to a modest but significant improvement in overall survival.
An advisory panel reviewed follow-up data on checkpoint inhibitors, voting to maintain four approvals and rescind two.
Additions of the checkpoint inhibitor led to improved survival compared with chemotherapy alone.
Although the improvement in survival with immunotherapy was modest, it is noteworthy because SCLC has been such a recalcitrant disease.
After finding a protein that smoking affects to drive head and neck cancer, investigators hope manipulating it will prove beneficial.
Keytruda and Imfinzi showed response rates and safety profiles similar to those seen in HIV-negative people.
A third of patients taking neoadjuvant Opdivo for inoperable advanced liver cancer had complete responses in an early analysis.
Seventy percent of liver cancer patients had either a partial response or stable disease.
Checkpoint inhibitor alone or in combination shows benefits for different types of colorectal cancer.
Checkpoint inhibitor immunotherapy, alone or in combination with chemotherapy, shows promise for advanced non-small-cell lung cancer.
In non-small cell lung cancer, new drugs like brigatinib and crizotinib can dramatically shrink tumors with an ALK alteration.
James Allison and Tasuku Honjo recognized for immune checkpoint discoveries.
Immunotherapy led to better outcomes for patients with inoperable non-small-cell lung cancer.
The experimental antibody BAY1905254 targets the newly discovered checkpoint ILDR2.
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