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Scientists studied how a series of stepwise mutations in normal blood cells could trigger the transformation to cancer.
Tumors with large numbers of genetic mutations may be especially susceptible to treatment with immunotherapy.
Tumors known as gliomas generally don’t respond to the immunotherapy drugs even when the tumor cells are “hypermutated."
Researchers have long sought a way to select the people who are most likely to respond to the treatments, and spare others the side effects.
The program proved as accurate as experienced pathologists at diagnosing adenocarcinomas and squamous cell carcinomas.
An estimated 29,430 men will die from prostate cancer in 2018; it is second only to lung cancer as a cause of cancer death among U.S. men.
Kevan Shokat, PhD, called the newly discovered mechanism for cancer-causing mutations a “complete 180-degree unexpected result.”
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