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Ivosidenib (Tibsovo) plus chemotherapy may soon be an option for those with leukemia that has an IDH1 mutation.
For those with undetectable minimal residual disease, treatment discontinuation was as effective as staying on Imbruvica.
The drug targets cancer’s survival proteins, making them more vulnerable to treatments that cause cancer cells to self-destruct.
The regimen is approved for adults age 75 or older and those who cannot use intensive induction chemotherapy.
Imbruvica, Calquence and Venclexta demonstrate good results in combination regimens.
In a recent study, Dana-Farber scientists and others uncovered a key part of why some patients eventually become resistant to Venclexta.
Targeted therapy combination reduced the risk of disease progression or death by 65% in a randomized study.
Study found Venclexta plus Gazyva (obinutuzumab) delayed disease progression in previously untreated patients.
Imbruvica plus Gazyva is the first chemotherapy-free regimen for chronic lymphocytic leukemia.
Researchers believe their greater understanding of leukemia stem cells will lead to more treatment options for people with the blood cancer.
Researchers called the results of treatment using Venclexta (venetoclax) and Vidaza (azacitidine) “remarkably impressive.”
Imbruvica-based treatment may also work better than intensive chemotherapy for younger patients.
Customized cell therapy plus Imbruvica leads to high response rate.
Venclexta plus Gazyva reduces risk of disease progression or death.
Approval was based on improves progression-free survival in the MURANO trial.
Oncologists are excited about the increased options available to patients, and about the promise of even more new therapies to come.
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